Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice
Shauni Doms, Hanna Fokt, Malte Christoph Rühlemann, Cecilia J. Chung, Axel Künstner, Saleh Mohamed Ibrahim, André Franke, Leslie M. Turner, John F. Baines
The paper uses genetic mapping in hybrid mice to show host genetics shape gut microbiome traits, identifies 443 loci influencing 123 taxa, and finds disease-related genes.
eLife · Jun 14, 2022Peer-reviewedGenetics