Saleh Mohamed Ibrahim

This study shows gut microbiota influences disease severity in an experimental pemphigoid model, with specific taxa linked to protection or inflammation.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

The paper presents a T2T-level pangenome of 58 Emirati genomes, revealing genomic diversity comparable to the Human Pangenome Reference Consortium.

The paper examines how mitochondrial haplotype and mito-nuclear matching influence somatic mutation and selection in aging mice across tissues.

The paper characterizes mitochondrial genetic variation in North and East Africa, identifying novel haplogroups and phylogenetic deviations.

The paper uses genetic mapping in hybrid mice to show host genetics shape gut microbiome traits, identifies 443 loci influencing 123 taxa, and finds disease-related genes.

The paper shows that loss of p32 leads to energy deficiency and impaired goblet cell differentiation in ulcerative colitis, suggesting nutritional intervention could prevent this.

The paper presents the first de novo assembled Egyptian genome and population-based genetic variation data, highlighting differences in allele frequencies and linkage disequilibrium between Egyptians and Europeans.

This study shows that a mutation in mt-Nd2, a mitochondrial complex I gene, reduces lifespan and increases glucose intolerance in mice by affecting tryptophan levels and aging pathways.

The paper describes a method using pathway maps to analyze omics data, focusing on cellular senescence and its role in disease.

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.

The paper shows that combining mitochondrial tRNA and OXPHOS mutations in mice leads to reduced lifespan and physical condition with age, but not with single mutations.