This study identifies three psychosis neurosubtypes using imaging data, showing distinct connectivity patterns and supporting their biological validity through relative alignment.

Molecular Psychiatry · Oct 9, 2026Peer-reviewedNeuroscience

Individuals with Intermittent Explosive Disorder Exhibit Idiosyncratic Neural Responses during Social-emotional Processing

Jiajie Chen, Sarah Keedy, Emil F. Coccaro, Yuan Chang Leong

The paper examines neural responses in individuals with intermittent explosive disorder (IED) during social-emotional processing and finds idiosyncratic neural patterns compared to healthy controls.

bioRxiv · Mar 17, 2026 · PreprintNeuroscience

Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations

Cuihua Xia, Ney Alliey‐Rodriguez, Carol A. Tamminga, Matcheri S. Keshavan, Godfrey D. Pearlson, Sarah Keedy, Brett A. Clementz, Jennifer E. McDowell, David Parker, Rebekka Lencer, S. Kristian Hill, Jeffrey R. Bishop, Elena I. Ivleva, Cindy H. Wen, Rujia Dai, , Elliot S. Gershon

The paper analyzes psychosis biotypes using ancestry-adjusted polygenic risk scores and identifies genomic associations with specific biotypes in brain transcriptomes.

Molecular Psychiatry · Dec 21, 2024Peer-reviewedGenetic & Genomic Medicine

Genetic Analysis of Deep Phenotyping Projects in Common Disorders

Elliot S. Gershon, Godfrey D. Pearlson, Matcheri S. Keshavan, Carol A. Tamminga, Brett A. Clementz, P.F. Buckley, Ney Alliey‐Rodriguez, C. Liu, John A. Sweeney, Sarah Keedy, Shashwath A. Meda, Neeraj Tandon, Rebecca Shafee, Jeffrey R. Bishop, Elena I. Ivleva

The paper discusses challenges in genetic analysis of deep phenotyping projects in common disorders and highlights advances in imputation and GWAS methods to address these challenges.

Schizophrenia Research · Oct 20, 2017Peer-reviewedGenetics

Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study

Ney Alliey‐Rodriguez, Tamar A Grey, Rebecca Shafee, Jaya L. Padmanabhan, Neeraj Tandon, Madeline Klinger, Jonathan Spring, Lucas Coppes, Katherine S. Reis, Matcheri S. Keshavan, Diane Gage, Steven A. McCarroll, Jeffrey R. Bishop, Scot Kristian Hill, James L. Reilly, , Elliot S. Gershon

The paper reports GWAS findings linking common variants in NRXN1, LRP1B, and RORA to increased ventricular volumes in psychosis, using deep phenotyping data from 1,115 cases and controls.

bioRxiv · Aug 16, 2017 · PreprintGenetics