Wendy Béguelin

Intravital single-cell behavior profiling reveals disrupted germinal center B cell motility and interactions by EZH2 gain-of-function mutation

This study uses intravital imaging and single-cell analysis to show that EZH2 mutations alter GC B cell motility and interactions, promoting lymphomagenesis.

Spatial Proteomics Reveals Dual-Compartment Immune Evasion Architecture and Core Lymphomagenic Stromal Niches in Follicular Lymphoma

This study uses spatial proteomics to reveal immune evasion mechanisms in follicular lymphoma, identifying VISTA and CD14-high follicular dendritic cells as therapeutic targets.

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

Data-driven simulations elucidate how lymphocyte motility behaviors influence cell-cell interactions within germinal centers

The paper develops a computational framework to quantify lymphocyte motility behaviors and predict their impact on B-T interactions in germinal centers, finding that differential motility enhances B-T interaction rates.

Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma

This study investigates how mutant EZH2 affects the epigenetic network in B cell lymphomas, showing it increases epigenetic heterogeneity and dominates over KMT2D mutations.

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

ChromaFold predicts 3D chromatin contact maps from scATAC-seq data, outperforming bulk-based methods and enabling cell-type-specific interaction analysis.