Author

Jiyun Zhou

Johns Hopkins UniversityORCID 0000-0002-2145-2976Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Assay:DNA methylation· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:fine-mapping· 1 Research Focus:imputation· 1 Approach:transformer / foundation model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Daniel R. WeinbergeriD· 3 shared Shizhong HaniD· 3 shared Chongyuan LuoiD· 2 shared Brady J. MaheriD· 1 shared Chunyu LiuiD· 1 shared Cuining LiuiD· 1 shared Hanqing LiuiD· 1 shared Joel E. KleinmaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenetics

Daniel R. WeinbergerORCID

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3 papers

Recent·Most cited

Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders

Jiyun Zhou, Cuining Liu, Xiaoming Liu, Yuan Zhang, Yu Wei, Joo Heon Shin, Brady J. Maher, Chunyu Liu, Chongyuan Luo, Kai Wang, Daniel R. Weinberger, Shizhong Han

The paper identifies distinct DNA methylation mechanisms for common and rare noncoding genetic risk in brain disorders using deep learning and single-nucleus DNAm data.

bioRxiv · Mar 11, 2026 · PreprintGenetics

scMeFormer: a transformer-based deep learning model for imputing DNA methylation states in single cells enhances the detection of epigenetic alterations in schizophrenia

Jiyun Zhou, Chongyuan Luo, Hanqing Liu, Matthew G. Heffel, Richard E. Straub, Joel E. Kleinman, Thomas M. Hyde, Joseph R. Ecker, Daniel R. Weinberger, Shizhong Han

bioRxiv · Jan 25, 2024 · PreprintGenomics

Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders

Jiyun Zhou, Daniel R. Weinberger, Shizhong Han

This paper introduces a transformer-based model to predict cell type-specific DNA methylation regulatory variants and improves fine mapping for brain disorders.

bioRxiv · Jan 18, 2024 · PreprintGenetics