Joo Heon Shin

The paper identifies distinct DNA methylation mechanisms for common and rare noncoding genetic risk in brain disorders using deep learning and single-nucleus DNAm data.

This study investigates the genetic regulation of miRNA expression in human brain tissues and identifies miRNAs associated with psychiatric and neurodegenerative disorders.

The paper performs transcriptomic analysis of the human habenula and identifies molecular changes associated with schizophrenia risk and illness state.

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

This study investigates TrkB signaling in the lateral septum using RNA-seq, identifying gene expression changes linked to psychiatric and neurodegenerative disorders.

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.

The paper examines how genetic ancestry influences gene expression and DNA methylation in admixed African/Black Americans, showing environmental and genetic factors affect brain disease risk.

The paper identifies and validates copy number variants in single human neurons using a new method, revealing nonrandom CNV locations and complex karyotypes in a subset of neurons.

The paper identifies differentially expressed genes in PTSD and MDD across brain regions, highlighting shared and unique transcriptional patterns and immune-related pathways.

The paper manipulates genomic risk signatures for schizophrenia in brain co-expression networks to explore their impact on gene connectivity and variability.

This study identifies somatic SNVs in non-cancerous human brain tissues and establishes best practices for detecting low-frequency variants.

The paper identifies transcriptomic differences in human pluripotent stem cells that correlate with retinoic acid response and neural fate bias.

This paper shows that primed human pluripotent stem cells can differentiate to trophoblast stem cells without becoming naive, using specific signaling conditions and revealing a transcriptional network involving BMP5/7 and GATA3.

This study shows that different SynGAP splice variants have distinct roles in synaptic plasticity and dendritic development through unique spatiotemporal expression and phase separation properties.

The paper models the progression of human neural stem cells in vitro, showing they transition through organizer states before committing to cortical excitatory or inhibitory neuronal fates.

The paper identifies a distinct population of hippocampal neurons projecting to the prelimbic cortex that regulate context fear memory recall through molecular and circuit-specific mechanisms.

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

This study characterizes DNA methylation changes in human neurons across development, identifies distinct methylation patterns, and links them to heritable brain-related phenotypes.

This study evaluates biases in small RNA sequencing methods, showing that UMIs improve accuracy and highlighting limitations in current miRNA and isomiR quantification.

The paper identifies a gene co-expression module enriched for schizophrenia risk genes and shows its association with treatment response in schizophrenia patients.

The paper characterizes nuclear and cytoplasmic transcriptomes in human cortex development and finds increased nuclear retention in mature brain, linked to psychiatric disease gene regulation.

The paper identifies differentially methylated DNA sites and associated genes in Alzheimer’s disease across multiple brain regions, linking them to gene expression and biological processes.

This study identifies and prioritizes gene sets linked to schizophrenia risk using co-expression network analysis in human brain data, highlighting modules associated with diagnosis and polygenic risk scores.

The paper replicates a postmortem association of LINC01268 with violent suicide and links it to in vivo aggression and prefrontal cortex function in living individuals.

This study shows that BDNF from promoters I and II is essential for maternal behavior in female mice by regulating oxytocin expression and signaling through TrkB in oxytocin neurons.

This study identifies gene expression changes in the prenatal human cortex due to maternal smoking and links them to neuropsychiatric disorder risk genes.

The paper identifies 237 genes associated with schizophrenia using RNA sequencing and eQTL analysis, showing enrichment for developmentally regulated synaptic genes.

The paper introduces xMD-miRNA-seq to obtain in vivo miRNA expression from colon epithelial cells using FFPE tissues, showing cell-specific miRNA profiles comparable to other epithelial sources.

The paper compares mouse models of syndromic ASD with human ASD brain data to identify shared myelination and axon development disruptions across both syndromic and idiopathic ASD.