Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders
Jiyun Zhou, Cuining Liu, Xiaoming Liu, Yuan Zhang, Yu Wei, Joo Heon Shin, Brady J. Maher, Chunyu Liu, Chongyuan Luo, Kai Wang, Daniel R. Weinberger, Shizhong Han
The paper identifies distinct DNA methylation mechanisms for common and rare noncoding genetic risk in brain disorders using deep learning and single-nucleus DNAm data.
bioRxiv · Mar 11, 2026 · PreprintGenetics