Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
Raquel Chamorro-García, Carlos Díaz-Castillo, Bassem M. Shoucri, Heidi Kaech, Ron Leavitt, Toshi Shioda, Bruce Blumberg
The paper shows that ancestral exposure to the obesogen tributyltin in mice leads to transgenerational obesity in unexposed F4 male descendants through heritable changes in genome architecture.
Nature Communications · Dec 4, 2017Peer-reviewedDevelopmental Biology