Toshi Shioda

Ancestral tributyltin exposure produces male-specific brown adipose thermogenic dysregulatoin

This study shows that ancestral tributyltin exposure impairs male brown adipose thermogenic function, leading to increased fat accumulation and reduced mitochondrial capacity after high-fat diet.

Induction of Meiosis from Human Pluripotent Stem Cells

This study develops a method to induce meiosis from human pluripotent stem cells, showing key meiotic stages and gene expression similar to in vivo oogonia.

Revisiting the Use of Structural Similarity Index in Hi-C

The paper shows that the structural similarity index from CHESS is unreliable due to noise in Hi-C data, warning against its biological interpretation.

Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa-Like Cells via Transcription Factor Overexpression

This study generates functional ovarian granulosa-like cells from human iPSCs by overexpressing NR5A1 and RUNX1 or RUNX2, enabling the formation of ovary-like organoids with germ cells.

Heritable changes in chromatin contacts linked to transgenerational obesity

This study shows that exposure to the obesogen tributyltin causes heritable changes in chromatin structure in germ cells, leading to transgenerational obesity in male offspring.

miR-223 Plays A Critical Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity

The paper identifies miR-223 as a key regulator of TBT-induced adipogenesis in MSCs and its transgenerational role in obesity.

Viral proteins and virus-like particles of the LTR5_Hs endogenous retrovirus in human primordial germ cell-like cells

The paper identifies LTR5_Hs viral proteins and virus-like particles in hPGCLCs, showing their activation during early germ cell development and suppression upon gonadal anlagen settlement.

Rapid Human Oogonia-like Cell Specification via Combinatorial TF-Directed Differentiation

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.

Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice

The paper shows that ancestral exposure to the obesogen tributyltin in mice leads to transgenerational obesity in unexposed F4 male descendants through heritable changes in genome architecture.