A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity
Yuta Shimanaka, Marc J. P. M. Tol, Christian Rocha-Roa, Matthew J. Jellinek, Liujuan Cui, Aaron S. Bender, Alexander H. Bedard, Madeleine G. Milner, Bruno N. Melillo, Bassem M. Shoucri, Adrian M. Wong, Kevin J. Williams, Linsey Stiles, Michael Shum, Thomas A. Weston, , Peter Tontonoz
The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.
bioRxiv · May 15, 2025 · PreprintPhysiology