Author

Lars E.T. Jansen

University of OxfordORCID 0000-0002-2158-0345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Paweł MikulskiiD· 3 shared Izma Abdul‐ZaniiD· 2 shared Sahar TehraniiD· 2 shared Anna Kogan· 1 shared Ben L. CartyiD· 1 shared Brent James RyaniD· 1 shared Daniele FachinettiiD· 1 shared Danilo DubocaniniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Paweł MikulskiORCID

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3 papers

Recent·Most cited

GenomicsNature Structural & Molecular BiologyPeer-reviewedNov 25, 2025

Heterochromatin boundaries maintain centromere position, size and number

Ben L. Carty, Danilo Dubocanin, Marina Murillo-Pineda…·Lars E.T. Jansen

The paper investigates how heterochromatin boundaries maintain centromere position, size, and number through specific histone modifications and methyltransferases.

19 citationstop 3%

humanDNA methylation

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedApr 4, 2025

Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

Paweł Mikulski, Sahar Tehrani, Anna Kogan…·Lars E.T. Jansen

The paper identifies chromatin modifications and regulatory elements that enable long-term transcriptional memory of IFNγ exposure in immune cells.

15 citationstop 5%

humanChIP-seq

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Molecular BiologyThe EMBO JournalPeer-reviewedJun 5, 2023

STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory

Sahar Tehrani, Paweł Mikulski, Izma Abdul‐Zani…·Lars E.T. Jansen

The paper shows STAT1 is essential for establishing IFNγ-induced transcriptional memory but not for maintaining it, with GBP genes being poised for rapid activation upon secondary exposure.

47 citationstop 3%

humanbulk RNA-seq

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