Selective S1PR1 activation improves brain infarction, neurological outcome, and cerebrovascular endothelial health following experimental ischemic injury
Samuel Xiang-Yu Shi, Yujing Li, Trevor S. Wendt, Kaibin Shi, Wei‐Na Jin, Qiang Liu, Rayna J. Gonzales
This study shows that selective S1PR1 activation reduces brain infarct volume and improves neurological outcomes in mice after stroke, while also enhancing endothelial cell survival under hypoxic conditions.
bioRxiv · Mar 27, 2023 · PreprintNeuroscience