Kaibin Shi

This study identifies elastase (ELANE) as a driver of white matter damage in cerebral small vessel disease, showing its role in oligodendrocyte death and proposing it as a therapeutic target.

This study shows that selective S1PR1 activation reduces brain infarct volume and improves neurological outcomes in mice after stroke, while also enhancing endothelial cell survival under hypoxic conditions.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.