Trevor S. Wendt

Cerebrovascular Claudin-5 Isoform Expression Correlates with Worsened Stroke Outcomes Following Thromboembolic Stroke

This study shows that ischemic stroke causes changes in claudin-5 isoform expression in rats, which correlate with worse neurological outcomes and BBB dysfunction.

Urban PM2.5 Impairs Blood-Brain Barrier Integrity and Enhances LOX-1 Expression in Human Brain Endothelial Cells

This study shows urban PM2.5 exposure impairs blood-brain barrier integrity and increases LOX-1 expression in human brain endothelial cells, suggesting a mechanism linking air pollution to cerebrovascular disease.

Differential S1PR Expression and Altered Barrier, and Inflammatory Marker Levels in Human Brain Endothelial Cells Following Acute Ischemia-Reperfusion Like Injury

This study examines changes in S1PR expression and endothelial barrier/inflammatory markers in human brain endothelial cells after ischemia-reperfusion injury, finding increased S1PR1 expression and potential therapeutic implications.

LOX-1 and MMP-9 inhibition attenuates the detrimental effects of delayed rt-PA therapy and improves outcomes after acute ischemic stroke

This study shows that inhibiting LOX-1 and MMP-9 with drugs improves outcomes after delayed rt-PA treatment in stroke by reducing hemorrhage and edema.

Selective S1PR1 activation improves brain infarction, neurological outcome, and cerebrovascular endothelial health following experimental ischemic injury

This study shows that selective S1PR1 activation reduces brain infarct volume and improves neurological outcomes in mice after stroke, while also enhancing endothelial cell survival under hypoxic conditions.