Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality
Arti Navare, Fred David Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell Lewis Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe‐Huntington, Mike Tyers, John D. Aitchison
The paper demonstrates that viral-induced hypomorphs of GBF1 can be targeted using synthetic lethality to selectively kill virus-infected cells.
The Journal of Cell Biology · Aug 27, 2022Peer-reviewedMolecular Biology