Jasmin Coulombe‐Huntington

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

The paper identifies PRR14L as a gene affecting mitotic fidelity and sensitivity to MPS1 inhibition through a CRISPR/Cas9 screen and proximity labeling.

FiGS-MoD identifies human signaling motifs by integrating residue features and HMMs, outperforming MEME and providing 221,840 SLiM predictions.

The paper demonstrates that viral-induced hypomorphs of GBF1 can be targeted using synthetic lethality to selectively kill virus-infected cells.

The paper identifies 2,280 essential genes in human B-cell lymphoma cells using an EKO library and RANKS tool, revealing context-specific essentiality and evolutionary patterns.