Fred David Mast

This study shows that host oxidative stress primes Mycobacterium tuberculosis for rapid antibiotic resistance evolution by creating permissive genomic backgrounds that accelerate resistance mutations.

This study shows that TOR and heat shock pathways regulate peroxisome biogenesis during proteotoxic stress in yeast and human cells.

This paper develops a conditional Cas9 system for stage-specific gene editing in P. falciparum, demonstrating its use in disrupting uncharacterized genes and identifying stage-specific phenotypes.

The paper uses two computational methods to reconstruct kinase phosphosignaling networks regulating endothelial barrier integrity from temporal data.

perox-per-cell automates image-based quantification of peroxisome features in yeast cells, matching manual counts and enabling high-throughput analysis.

The paper identifies receptor tyrosine kinases (RTKs) that regulate dengue virus infection in hepatocytes and shows their potential as therapeutic targets.

The paper predicts synthetic lethal antiviral targets by analyzing omics data and CRISPR KO screens, finding common targets across SARS-CoV-2 and influenza infections.

The paper demonstrates that viral-induced hypomorphs of GBF1 can be targeted using synthetic lethality to selectively kill virus-infected cells.