Timothy R.H. Regnault

This paper identifies placental transcriptomic changes associated with maternal BMI through a meta-analysis of RNA-seq data, finding significant genes and pathways linked to inflammation and metabolism.

This study uses MRI to identify placental insufficiency in IUGR pregnancies and links metabolic changes to fetal growth patterns in guinea pigs.

The paper examines white matter microglial morphology changes with aging in growth-restricted guinea pig offspring and finds no exacerbation of these changes compared to controls.

This study identifies altered placental morphology and metabolomic profiles in metabolically healthy obese pregnancies, highlighting unique metabolic pathways and potential biomarkers.

This study shows that placental hIGF1 nanoparticle treatment in guinea pigs reduces FGR-related kidney structural and signaling pathway changes.

This study shows that placental hIGF1 nanoparticle gene therapy in guinea pigs reduces FGR-associated liver metabolic dysregulation in a fetal sex-specific manner.

This review examines the effects of maternal fructose consumption during pregnancy on maternal, fetal, and offspring adiposity in rodents, finding associations with increased hepatic and whole-body fat.

This study shows that high maternal adiposity during pregnancy increases offspring susceptibility to diet-induced hepatosteatosis, with lipidomic changes linked to intrauterine environment effects.

This study investigates how hyperglycemia affects placental trophoblast cell metabolism and nutrient storage using BeWo cells, finding increased glycogen and triglyceride stores but no changes in mitochondrial function.