Konstantin Weißenow

The paper analyzes the DNA sequence and methylome of Jonathan, a 192-year-old giant tortoise, to identify epigenomic features associated with extreme longevity.

ProstT5, a ProtT5 fine-tuned to translate between amino acids and Foldseek 3Di tokens, predicts structure strings for remote homology search and performs inverse folding.

MutAmore generates 3D mutation movies of proteins by predicting structural conformations of all possible single amino-acid variants and visualizing them as color-coded animations.

EMBER3D predicts protein 3D structures from single sequences rapidly, enabling real-time analysis of mutation effects and structural changes.

The paper introduces bindAdjust, a method that improves binding predictions by incorporating structural information from AlphaFold2, enhancing recall for small molecule binding and expanding predictions to larger binding sites.

This paper presents a method using protein language model embeddings for alignment-free protein structure prediction, achieving performance comparable to co-evolution-based methods at lower computational cost.

The paper introduces bindEmbed21, a deep learning method using protein embeddings to predict binding residues for metal ions, nucleic acids, and small molecules, achieving high accuracy without using MSAs or structural data.