Author

Liangyue Guo

Changping LaboratoryORCID 0000-0002-2209-8227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:CUT&Tag· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Allen Chunlong GuoiD· 1 shared Baihui TianiD· 1 shared Binghua LiuiD· 1 shared Di WangiD· 1 shared Fanhao MengiD· 1 shared Haibin LiuiD· 1 shared Hongzhun WangiD· 1 shared Jie LiniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Allen Chunlong GuoORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 23, 2026

High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation

Qilin Yu, Liangyue Guo, Xiayan Qin…·Mingchen Chen

This paper designs high-affinity protein binders using a computational framework combining flow matching and in silico maturation, achieving picomolar and nanomolar affinities without experimental screening.

3 citations

protein structuredeep learning

BioinformaticsbioRxivPreprintNov 2, 2023

An end-to-end approach for protein folding by integrating Cryo-EM maps and sequence evolution

Pan Li, Liangyue Guo, Haibin Liu…·Allen Chunlong Guo

This study introduces SMARTFold, a deep learning model that integrates Cryo-EM maps and sequence alignment to predict protein structures, outperforming existing methods on benchmark datasets.

5 citations

CUT&Tagdeep learning