BiochemistrybioRxivPreprint
High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation
Qilin Yu, Liangyue Guo, Xiayan Qin…·Mingchen Chen
This paper designs high-affinity protein binders using a computational framework combining flow matching and in silico maturation, achieving picomolar and nanomolar affinities without experimental screening.
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