Author

Qilin Yu

Changping LaboratoryORCID 0000-0002-0120-6604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Mingchen CheniD· 2 shared Baihui TianiD· 1 shared Di WangiD· 1 shared Di WangiD· 1 shared Hongzhun WangiD· 1 shared Jie LiniD· 1 shared Liangyue GuoiD· 1 shared Xiayan QiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Mingchen ChenORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 23, 2026

High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation

Qilin Yu, Liangyue Guo, Xiayan Qin…·Mingchen Chen

This paper designs high-affinity protein binders using a computational framework combining flow matching and in silico maturation, achieving picomolar and nanomolar affinities without experimental screening.

3 citations

protein structuredeep learning

𝕏 PostBluesky

BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedJul 17, 2025

AF3Score: A Score-Only Adaptation of AlphaFold3 for Biomolecular Structure Evaluation

Yu Liu, Qilin Yu, Di Wang, Mingchen Chen

AF3Score is a score-only adaptation of AlphaFold3 that evaluates biomolecular structures without iterative refinement, showing improved performance in binder screening and fold-switching protein analysis.

9 citations

protein structuredeep learning

𝕏 PostBluesky