Sox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness.
Maria Faleeva, Sadia Ahmad, Steven Lynham, Gabriel C. Watson, Meredith Whitehead, Susan Cox, Catherine M. Shanahan
This study shows Sox9 regulates ECM stiffness and composition in vascular smooth muscle cells, promoting vascular ageing through a feedback loop between senescence and ECM changes.
bioRxiv · May 3, 2023 · PreprintMolecular Biology