Susan Cox

Extracting biological structure and heterogeneity from the nano to the macro scale

This paper introduces SQUASSH, a convolutional neural network that fits structural models to fluorescence microscopy data to quantify variability across biological scales.

Image quality metrics fail to accurately represent biological information in fluorescence microscopy

The paper shows that image quality metrics (IQMs) are unreliable for guiding fluorescence microscopy image processing as they do not correlate with downstream biological analysis performance.

A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

This study uses a hybrid computational model to show that increased ECM stiffness inhibits invasion in aggressive cancer cells but not in non-invasive ones.

Sox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness.

This study shows Sox9 regulates ECM stiffness and composition in vascular smooth muscle cells, promoting vascular ageing through a feedback loop between senescence and ECM changes.

Extracellular matrix assembly stress drives Drosophila central nervous system morphogenesis

This study shows that extracellular matrix assembly stress actively drives morphogenesis in Drosophila ventral nerve cord by generating surface tension during collagen-IV network formation.