Jeff Wereszczynski

This study investigates how the N-terminal regions of CENP-A contribute to the open DNA conformation of centromeric nucleosomes compared to canonical H3 nucleosomes.

This study uses molecular dynamics simulations to show how H2A and H2B ubiquitination opposingly affect nucleosome stability and assembly kinetics through structural changes.

The paper uses molecular dynamics simulations to study how mutations in the bacteriophage λ Cro repressor alter its DNA-binding properties and regulatory function.

This study uses molecular dynamics simulations to show how viral nucleosome-like particles differ in structure and thermodynamic stability from eukaryotic nucleosomes.

This study uses molecular simulations to show how BPTF's PHD finger and bromodomain bind to nucleosomes, altering histone-DNA interactions and destabilizing the nucleosome core.

This study uses molecular dynamics simulations to show how potassium and magnesium ions affect nucleosome binding to mica surfaces, with potassium allowing stable binding with less structural change.

The paper shows CENP-N promotes centromere-specific nucleosome stacking and higher order chromatin structures in vitro and in cells.