Karolin Luger

An expanded evolutionary landscape of H3 histones with variants that destabilize nucleosomes and promote chromatin accessibility

This study identifies two novel H3 histone variants in Hofstenia miamia that destabilize nucleosomes and promote chromatin accessibility during regeneration.

PARP1 Exhibits an Enzymatically Inactive Chromatin Binding Mode

This study identifies an enzymatically inactive chromatin binding mode of PARP1 that compacts undamaged chromatin without triggering catalytic activation.

Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism

This study determines the structure of human HIRA with a nucleosome, revealing its active role in a stepwise nucleosome assembly mechanism.

TFAM organizes DNA into compact higher order structures

This study investigates how TFAM organizes mtDNA into compact higher order structures through biochemical and structural analysis of TFAM oligomerization on longer DNA.

Histone diversity in the archaeal domain of life

The paper surveys histone diversity in archaea using bioinformatics and simulations, identifying five histone types and their genomic strategies.

Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures.

The paper identifies a unique H2B-H2A histone variant in Melbournevirus that forms structurally distinct nucleosomes with reduced DNA binding capacity.

Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone

The paper reports the structure of nucleosomes formed by Medusavirus medusae histones, showing similarities to eukaryotic and Melbournevirus nucleosomes and revealing unique features of viral histone function.

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation Hotspots

This study shows SMARCAD1 resolves R-loops at replication forks, preventing genome instability and cancer mutations.

Histone-organized chromatin in bacteria

This study shows that histones are essential and form chromatin in bacteria, with a unique DNA binding mode compared to archaea and eukaryotes.

CENP-N promotes the compaction of centromeric chromatin

The paper shows CENP-N promotes centromere-specific nucleosome stacking and higher order chromatin structures in vitro and in cells.

Melbournevirus-encoded histone doublets are recruited to virus particles and form destabilized nucleosome-like structures

The paper shows that large DNA viruses encode fused histone doublets that are targeted to viral factories and assemble into open nucleosome-like structures.