Alexander V. Maltsev

Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest

This study shows cardiac pacemaker cells use stochastic resonance to maintain rhythm at low heart rates, improving reliability in noisy conditions.

A New Fight-or-Flight Pacemaker Mechanism via Ryanodine Receptor Abundance and Superclustering

This paper uses dSTORM to visualize RyR clusters in rabbit SANCs and develops a model showing superclustering and RyR density changes modulate APCL during βAR stimulation.

DeepBranchAI: A Novel Cascade Workflow Enabling Accessible 3D Branching Network Segmentation

DeepBranchAI reduces annotation time for 3D branching network segmentation by using a cascade workflow that transforms sparse labels into comprehensive training data.

Proton tunneling at the ryanodine receptor Ca2+ activation site provides temperature-invariant noise for robust Ca2+-induced Ca2+ release

Sinoatrial Node Impulses Emerge From Incessant, Unique Kinetic Transitions In Disordered Local Calcium Dynamics

The paper analyzes local calcium dynamics in mouse sinoatrial node cells to show how stochastic transitions in heterogeneous calcium oscillations generate rhythmic impulses.

Functional heterogeneity of cell populations increases robustness of pacemaker function in a numerical model of the sinoatrial node tissue

The paper uses a computational model to show that functional heterogeneity in pacemaker cells enhances the robustness of SAN function by enabling cooperative interactions between firing and dormant cells.