Author

Isabella K. He

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Akihiro OkamuraiD· 1 shared Alexander V. MaltseviD· 1 shared Alexandra E. Hong· 1 shared Alfred L. GeorgeiD· 1 shared Anna MaltseviD· 1 shared Carlos G. VanoyeiD· 1 shared Christine Q. Simmons· 1 shared Christopher H. ThompsoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Akihiro OkamuraORCID

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2 papers

Recent·Most cited

KCNH1 variants associated with neurodevelopmental disorders exhibit prominent gain-of-function

Christopher H. Thompson, Christine Q. Simmons, Isabella K. He, Nirvani P. Jairam, Reshma R. Desai, Esther Cha, Alexandra E. Hong, Jean‐Marc DeKeyser, Linda Laux, Michaelle Jinnette, Carlos G. Vanoye, Alfred L. George

The paper investigates functional properties of KCNH1 variants linked to neurodevelopmental disorders, finding most exhibit gain-of-function characteristics.

Brain · Oct 27, 2026Peer-reviewedNeuroscience

Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest

Akihiro Okamura, Isabella K. He, Alexander V. Maltsev, Rostislav Bychkov, Syevda Tagirova, Michael Wang, Anna Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev

This study shows cardiac pacemaker cells use stochastic resonance to maintain rhythm at low heart rates, improving reliability in noisy conditions.

Circulation Research · Jul 15, 2026Peer-reviewedBiophysics