Author

Shan Wang

Radboud University Medical CenterORCID 0000-0002-2222-6356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anna BleeckiD· 1 shared Chantal SchoenmakeriD· 1 shared Dirk SchubertiD· 1 shared Elly LewerissaiD· 1 shared Hans van BokhoveniD· 1 shared Ibrahim A. AkkouhiD· 1 shared Irene Santisteban Ortiz· 1 shared Jon-Ruben van RhijniD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anna BleeckORCID

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1 paper

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMay 1, 2022

Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

Shan Wang, Jon-Ruben van Rhijn, Ibrahim A. Akkouh…·Dirk Schubert

This study shows that SETD1A loss-of-function mutations increase dendritic complexity and neuronal bursting in human neurons via a hyperactive cAMP/PKA pathway, which can be rescued by pharmacological intervention.

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humanbulk RNA-seq