Author

Irene Santisteban Ortiz

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ambra VillaniiD· 1 shared Anna BleeckiD· 1 shared Ayush Aditya PaliD· 1 shared Chantal SchoenmakeriD· 1 shared Corinna Maria Biermeier· 1 shared Darren Gilmour· 1 shared Dirk SchubertiD· 1 shared Elly LewerissaiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Ambra VillaniORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivAug 27, 2025

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

Ambra Villani, Jana Sophie Wittmann, Tamara Wyss…·Francesca Peri

The paper develops a xenotransplantation model to study human microglia's processing of dying neurons, identifying a lipid-rich compartment called the gastrosome involved in neurodegeneration.

DOI 10.1038/s42003-026-09948-6

humanzebrafish

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NeuroscienceCell ReportsPeer-reviewedMay 1, 2022

Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

Shan Wang, Jon-Ruben van Rhijn, Ibrahim A. Akkouh…·Dirk Schubert

This study shows that SETD1A loss-of-function mutations increase dendritic complexity and neuronal bursting in human neurons via a hyperactive cAMP/PKA pathway, which can be rescued by pharmacological intervention.

69 citationstop 1%

humanbulk RNA-seq

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