Increased hippocampal epigenetic age in the Ts65Dn Mouse Model of Down Syndrome
Francesco Ravaioli, Fiorenza Stagni, Sandra Guidi, Chiara Pirazzini, Paolo Garagnani, Alessandro Silvani, Giovanna Zoccoli, Renata Bartesaghi, Maria Giulia Bacalini
The paper measures epigenetic age in Ts65Dn mice using a mouse-specific clock and finds increased hippocampal epigenetic age compared to controls, with DNA methylation changes similar to those in humans with Down syndrome.
Frontiers in Aging Neuroscience · May 21, 2024Peer-reviewedMolecular Biology