The paper measures epigenetic age in Ts65Dn mice using a mouse-specific clock and finds increased hippocampal epigenetic age compared to controls, with DNA methylation changes similar to those in humans with Down syndrome.

Frontiers in Aging Neuroscience · May 21, 2024Peer-reviewedMolecular Biology

Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing

Clément Crochemore, Claudia Chica, Paolo Garagnani, Giovanna Lattanzi, Steve Horvath, Alain R. Sarasin, Claudio Franceschi, Maria Giulia Bacalini, Miria Ricchetti

The paper identifies an epigenetic signature in Cockayne syndrome fibroblasts, showing similarities to normal aging and differences from other progeroid diseases.

bioRxiv · May 23, 2021 · PreprintMolecular Biology

A meta-analysis of brain DNA methylation across sex, age and Alzheimer's disease points for accelerated epigenetic aging in neurodegeneration

Camilla Pellegrini, Chiara Pirazzini, Claudia Sala, Luisa Sambati, Igor Yusipov, Alena Kalyakulina, Francesco Ravaioli, Katarzyna Malgorzata Kwiatkowska, Danielle Fernandes Durso, Mikhail Ivanchenko, Daniela Monti, Raffaele Lodi, Claudio Franceschi, Pietro Cortelli, Paolo Garagnani, Maria Giulia Bacalini

This study identifies age-associated DNA methylation changes in Alzheimer's disease, showing accelerated epigenetic aging but no significant sex interaction.

Frontiers in Aging Neuroscience · Mar 11, 2021Peer-reviewedGenetic & Genomic Medicine

Age-related DNA methylation changes are sex-specific: a comprehensive assessment

Igor Yusipov, Maria Giulia Bacalini, Alena Kalyakulina, Mikhail Krivonosov, Chiara Pirazzini, Noémie Gensous, Francesco Ravaioli, Maddalena Milazzo, Cristina Giuliani, Maria V. Vedunova, Giovanni Fiorito, Amedeo Gagliardi, Silvia Polidoro, Paolo Garagnani, Mikhail Ivanchenko, Claudio Franceschi

The paper assesses sex-specific DNA methylation changes with aging using whole blood datasets, finding 43% of sex-associated probes show age-related methylation changes and higher methylation variability in males.

Aging · Dec 3, 2020Peer-reviewedGenomics