Asthma-associated variants induce IL33 differential expression through a novel regulatory region
Ivy Aneas, Donna C. Decker, Chanie L. Howard, Débora R. Sobreira, Noboru J. Sakabe, Kelly M. Blaine, Michelle M. Stein, Cara Lynn Hrusch, Lindsey E. Montefiori, Juan J. Tena, Kevin M. Magnaye, Selene M. Clay, James E. Gern, Daniel J. Jackson, Matthew C. Altman, , Marcelo A. Nóbrega
The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.
bioRxiv · Sep 9, 2020 · PreprintGenomics