Carole Ober

The paper uses single-cell multi-omics data to identify asthma risk genes and their cell-type specific functions in lung immune cells.

The paper identifies CpG sites and pathways associated with gestational age and epigenetic age acceleration, and links perinatal exposures to these epigenetic changes.

The paper identifies disease-specific risk variants and shared effector genes in allergic diseases using functional fine-mapping and expression quantitative trait loci.

This study integrates functional genomics and statistical fine-mapping to identify causal variants, regulatory elements, and effector genes for adult-onset and childhood-onset asthma.

The paper develops gene expression prediction models for asthma-related tissues in African-ancestry populations and identifies 17 candidate causal asthma genes using transcriptome-wide association study.

This study identifies cell type-specific DNA methylation changes in airway epithelial cells linked to early-life RSV infection and their association with subsequent wheezing.

The paper identifies high-value CpGs in the human methylome associated with allergic sensitization using a custom array and WGBS data from airway epithelial cells.

This study identifies a genetic variant associated with reduced lung function in urban children and shows its mediation by DNA methylation linked to smoking exposure.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.

The paper analyzes longitudinal DNA methylation data to show that race-associated patterns are present at birth and primarily genetic, with strong genetic and weak non-genetic contributions.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

The paper identifies context-specific genetic mechanisms at asthma risk loci by integrating multi-omics data with GWAS results in airway epithelial cells exposed to rhinovirus.

This study identifies shared and distinct genetic risk factors for childhood and adult onset asthma using GWAS and transcriptome-wide analysis, finding 61 loci with 23 childhood-specific, 1 adult-specific, and 37 shared.

The paper uses gene co-expression networks in whole blood to identify molecular pathways associated with obese asthma, finding four modules linked to obesity and enriched for inflammatory pathways.

The paper identifies two new imprinted genes in a founder population using allele-specific expression and phased genotype data.

This paper introduces PQLseq, a method for heritability estimation and differential analysis in genomic sequencing studies, showing it provides unbiased heritability estimates and better power for differential analysis.

This study identifies genetic variants influencing the transcriptomic response to doxorubicin in cardiomyocytes and links them to anthracycline-induced cardiotoxicity risk.

The paper identifies rare non-coding variants in a founder population associated with plasma lipid traits using Bayesian methods and functional annotations.

The paper identifies parent of origin effects on 11 quantitative phenotypes in a Hutterite population, showing that these effects are common, clinically relevant, and often missed by traditional GWAS.

The paper reduces mitochondrial reads in ATAC-seq using CRISPR/Cas9 and a modified protocol, improving peak calling and reducing costs.

The paper designs a genotyping array (ADPC) for African-specific genetic variation using whole genome sequences from the CAAPA consortium, improving GWAS for African ancestry populations.

This study identifies novel asthma susceptibility loci in individuals of African ancestry through genome-wide association analysis and admixture mapping.

The paper identifies genetic variants associated with upper airway microbiome composition, highlighting mucosal immunity genes' role in shaping microbial communities.