Trans-ancestry polygenic models for the prediction of LDL blood levels: An analysis of the UK Biobank and Taiwan Biobank
Emadeldin Hassanin, Ko-Han Lee, Tzung‐Chien Hsieh, Rana S. Aldisi, Yi‐Lun Lee, Dheeraj Reddy Bobbili, Peter Michael Krawitz, Patrick May, Chien‐Yu Chen, Carlo Maj
This paper compares ancestry-specific and multi-ancestry polygenic risk scores for LDL prediction in East Asian populations using UK Biobank and Taiwan Biobank data, finding that multi-ancestry models are more generalizable.
medRxiv · Aug 3, 2023 · PreprintGenetic & Genomic Medicine