Huai‐Kuang Tsai

Predicting splicing patterns from the transcription factor binding sites in the promoter with deep learning

The paper uses deep learning to predict splicing patterns from promoter-bound transcription factor binding sites in human tissues.

PGSbuilder: An end-to-end platform for human genome association analysis and polygenic risk score predictions

PGSbuilder provides a web platform for GWAS and PRS analysis, enabling medical professionals to assess genetic risk using variant annotations and multiple PRS methods.

Identification and comparative analysis of long non-coding RNAs in the brain of fire ant queens in two different reproductive states

The paper identifies and compares long non-coding RNAs in fire ant queens across two reproductive states, finding differentially expressed lncRNAs associated with gene regulation during reproductive transitions.

Connecting MHC-I-binding motifs with HLA alleles via deep learning

This paper introduces MHCfovea, a deep learning framework that connects HLA alleles with binding motifs, revealing critical polymorphic residues for antigen discovery and vaccine design.

The borders of cis-regulatory DNA sequences harbor the divergent transcription factor binding motifs in the human genome

Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs

This study identifies that a significant portion of human lincRNAs may originate from pseudogenized protein-coding genes through comparative genomic analysis.