Sara Ortica

This paper introduces scReMeMber-Seq, a method to reconstruct single-cell trajectories by linking past and present transcriptomes using methylation-based memory recording.

The paper measures Notch3 signaling in zebrafish adult neural stem cells and shows it correlates with quiescence and stemness, with jagged1b promoting stemness through lateral induction.

This study identifies Prosaposin as a regulator of neural stem cell quiescence in zebrafish, showing it maintains deep quiescence and reduces activation.

The paper links apical size and deltaA expression to neural stem cell activation and division modes in zebrafish, showing their independence from Notch signaling.

The paper shows neural stem cells use local feedback mechanisms with delays to coordinate their division and maintain homeostasis in the adult brain.

The paper investigates the dynamics of adult neural stem cells in zebrafish, showing a hierarchical organization with reservoir and operational stem cells and an upstream progenitor population supporting long-term neurogenesis.