Millisecond nonlinear state changes during droplet coalescence identify therapeutic-antibody developability liabilities
Alexander N. St John, Jack Holland, Elizabeth Suk‐Hang Lam, Sejeong Lee, Piergiorgio Caramazza, A A Thomas, Shamit Shrivastava
The paper uses a liquid state machine to analyze antibody coalescence dynamics, identifying a biophysical liability linked to gel-like stiffening during droplet merging.
bioRxiv · Sep 24, 2026 · PreprintBiophysics