Author

Vaibhav P. Pai

Tufts UniversityORCID 0000-0002-2245-0753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Michael G. LeviniD· 3 shared Joshua BongardiD· 2 shared Thomas F. VarleyiD· 2 shared Caitlin GrassoiD· 1 shared James A. TraeriD· 1 shared Jeantine E. LunshofiD· 1 shared Megan M. SperryiD· 1 shared Michael LeviniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersSystems Biology

Michael G. LevinORCID

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Author profile →

4 papers

Recent·Most cited

Purinergic signaling disrupts emergent patterns of multicellular coordination in basal Xenobots.

Thomas F. Varley, Vaibhav P. Pai, Michaelk Levin, Joshua Bongard

This study shows that purinergic signaling disrupts multi-cellular coordination in basal Xenobots, altering information flow and integration.

bioRxiv · Jun 9, 2026 · PreprintSystems Biology

Behavioral, Physiological, and Transcriptional Mechanisms of Memory in a Synthetic Living Construct

Vaibhav P. Pai, James A. Traer, Megan M. Sperry, Yuxin Zeng, Michael Levin

This study investigates how synthetic living constructs, specifically Xenobots, sense and store memory through transcriptional and physiological changes after exposure to chemical stimuli.

bioRxiv · Mar 17, 2026 · PreprintSynthetic Biology

Identification of brain-like complex information architectures in embryonic tissue of Xenopus laevis organoids

Thomas F. Varley, Vaibhav P. Pai, Caitlin Grasso, Jeantine E. Lunshof, Michael G. Levin, Josh Bongard

The paper identifies complex information architectures in Xenopus laevis organoids, suggesting they exhibit integrated, complex systems despite being non-neural.

Communicative & Integrative Biology · Oct 7, 2025Peer-reviewedSystems Biology

Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain

Santosh Manicka, Vaibhav P. Pai, Michael G. Levin

The paper develops a bioelectric-genetic dynamical model to understand how spatial voltage patterns influence gene expression and brain development in Xenopus embryos, revealing mechanisms of information integration and plasticity.

iScience · Nov 4, 2023Peer-reviewedDevelopmental Biology