GeneticsbioRxivPreprint
Maintenance of quantitative genetic variance in complex, multi-trait phenotypes: The contribution of rare, large effect variants in two Drosophila species
Emma Hine, Daniel E. Runcie, Scott L. Allen…·Katrina McGuigan
The paper uses Bayesian Sparse Factor Genetic modelling to analyze gene expression traits in two Drosophila species, finding that most heritable trait covariation is due to a few extreme genotypes, suggesting the House of Cards model applies to co-expression phenotypes.
DOI 10.1101/2022.04.21.488876