Dong‐Woo Lee

Systematic analysis reveals an Mln1-dependent trade-off between metabolic flexibility and thermotolerance in Cryptococcus neoformans

This study identifies Mln1 as a regulator of metabolic flexibility and thermotolerance in Cryptococcus neoformans, revealing a trade-off between nutrient utilization and stress resistance.

Ultrastructural and Proteomic Signatures of Mechanoadaptive Fibroblast Remodeling across Microphysiological and Mesoscale Shear Platforms

This study shows sustained fluid shear stress drives a profibrotic phenotypic switch in fibroblasts across different mechanical platforms.

Programmable domestication of thermophilic bacteria through removal of non-canonical defense systems

This paper develops a method to make thermophilic bacteria genetically tractable by removing non-canonical defense systems, enabling stable genetic modification at high temperatures.

Cross-cohort analysis reveals conserved gut virome signatures and phage-encoded auxiliary functions in ulcerative colitis

The paper analyzes the gut virome across cohorts to identify conserved signatures and functional roles of phages in ulcerative colitis.

Dual Oxygen-Partitioned Co-Culture Uncovers Microbe-Specific Epithelial Stress and Homeostatic Programs

This study uses a dual oxygen-partitioned co-culture system to analyze how different gut microbes affect intestinal epithelial cells, revealing distinct stress and homeostatic responses.

Keratin degradation reflects a starvation survival strategy in Fervidobacterium islandicum AW-1

This study shows Fervidobacterium islandicum uses keratin degradation as a starvation survival strategy through proteases, redox reactions, and metabolic reprogramming.