Yeseul Choi

Systematic analysis reveals an Mln1-dependent trade-off between metabolic flexibility and thermotolerance in Cryptococcus neoformans

This study identifies Mln1 as a regulator of metabolic flexibility and thermotolerance in Cryptococcus neoformans, revealing a trade-off between nutrient utilization and stress resistance.

Host brain infection induces RNAi epimutation in Mucor circinelloides and enhances blood-brain barrier invasion

The paper shows brain infection induces RNAi epimutations in Mucor circinelloides that enhance blood-brain barrier invasion.

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

This study identifies a mycovirus, CnTV1, that persists in RNAi-deficient Cryptococcus neoformans isolates due to a NUMT insertion disrupting Ago1, and shows RNAi is critical for viral control.

Systematic Profiling of Essential Fungal Transcriptional Regulators Uncovers Ezt1 as a Central Pathobiological and Morphogenic Regulator in Cryptococcus neoformans

The paper identifies essential transcriptional regulators in Cryptococcus neoformans, highlighting Ezt1 as a key regulator of growth, drug response, and virulence.

Distinct STRIPAK subunits drive conserved and subunit-specific signaling programs in Cryptococcus neoformans

This study identifies distinct roles of STRIPAK subunits in Cryptococcus neoformans, showing that core subunits maintain genome stability and virulence while Mob3 promotes hypervirulence through enhanced host adaptation.

Fluorescent organelle markers in Cryptococcus neoformans: a versatile toolkit for live-cell subcellular localization

The paper develops a toolkit of fluorescent organelle markers in Cryptococcus neoformans to study subcellular localization and remodeling under various conditions and during sexual development.

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

Unisexual reproduction in the global human fungal pathogen Cryptococcus neoformans

This study shows that mutating the RIC8 gene in Cryptococcus neoformans enables unisexual reproduction involving meiotic recombination, suggesting it may be more common in nature than previously thought.

STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans

This study shows that STRIPAK complex defects in Cryptococcus neoformans lead to pseudosexual reproduction, affecting genome stability and inheritance.

Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans

This study identifies essential genes in the mating-type locus of Cryptococcus neoformans, showing that four genes are essential for viability while MYO2 is critical for pathogenicity despite not being essential.