Pathological R-loops in bacteria from engineered expression of endogenous antisense RNAs whose synthesis is ordinarily terminated by Rho
Apuratha Pandiyan, Jillella Mallikarjun, Himanshi Maheshwari, Jayaraman Gowrishankar
The paper shows engineered antisense RNAs in bacteria generate R-loops that disrupt genome integrity, confirming Rho's role in preventing toxic R-loops.
Nucleic Acids Research · Sep 12, 2024Peer-reviewedMicrobiology