Cellular heterogeneity-adjusted clonal methylation (CHALM) provides better prediction of gene expression
Jianfeng Xu, Jiejun Shi, Xiaodong Cui, Ya Cui, Jingyi Jessica Li, Ajay Goel, Xi Chen, Jianzhong Su, Jean‐Pierre J. Issa, Wei Li
The paper introduces CHALM, a methylation quantification method that accounts for cellular heterogeneity, improving the correlation between methylation and gene expression.
bioRxiv · Feb 23, 2020 · PreprintBioinformatics