Xi Chen

This paper identifies RACK1 as a redox-regulated hub that coordinates cellular stress responses through condensate-based microdomains, linking environmental stress to immune signaling and translational control.

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

This study shows that deleting ATP13A2 in adult mice leads to progressive dopaminergic degeneration and lysosomal issues, mimicking human neurodegenerative diseases.

This study investigates the interaction between VPS35 and α-synuclein in PD models and finds no significant functional or pathological interaction.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

The paper identifies circTulp4 as a circRNA that regulates its parental gene Tulp4, affecting nervous system function and potentially contributing to Alzheimer's disease pathogenesis.

This study develops a rat model of Parkinson's disease caused by the G2019S LRRK2 mutation and shows that kinase and GTPase activities are critical for neurodegeneration.

The paper introduces CHALM, a methylation quantification method that accounts for cellular heterogeneity, improving the correlation between methylation and gene expression.

coMethDMR identifies differentially methylated regions by first selecting co-methylated sub-regions and then testing their association with phenotypes using a mixed effects model.

The paper shows XBP1s regulates 12h-transcriptome rhythms in liver, aligning with central dogma information flow, and identifies GABP as a novel regulator.