Jean‐Pierre J. Issa

The paper re-analyzes over 7,000 RNA-seq samples to study transposable element differential expression in cancer and finds TE expression is more prone to batch effects and can be induced by various compounds.

The paper analyzes bone marrow microenvironment changes in HMA-resistant MDS patients treated with guadecitabine and atezolizumab, finding that long-term survivors show reduced immunosuppressive monocytes and expanded effector lymphocytes.

This study identifies ZNFX1 as a master regulator of epigenetically-induced pathogen mimicry and inflammasome signaling in ovarian cancer, linking its expression to disease progression and survival.

This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.

The paper introduces CHALM, a methylation quantification method that accounts for cellular heterogeneity, improving the correlation between methylation and gene expression.