Jianzhong Su

This paper introduces MAIS, a scalable neural interface system that enables adaptive neuromodulation through brain organoid-MEA integration and plasticity-driven dynamic decoding.

This study identifies polyQ assemblies in HD cells as dynamic structures that regulate Golgi function, showing that mutant HTT disrupts their stability and leads to Golgipathy.

MMpred improves de novo protein structure prediction by using a multimodal optimization protocol that enhances conformation sampling and model accuracy.

The paper identifies a novel 21q22.11 locus associated with COVID-19 susceptibility through GWAS and integrates eQTL data to show gene expression effects in lung tissue.

scTPA provides a web tool for analyzing single-cell RNA-seq data using pathway activation signatures to annotate cell types and identify functional patterns.

The paper identifies cell type-specific chromatin loops anchored at large DNA methylation nadirs, revealing their role in stem and progenitor cell function.

The paper introduces CHALM, a methylation quantification method that accounts for cellular heterogeneity, improving the correlation between methylation and gene expression.