Jonathan L. C. Lee

Appetitive Pavlovian goal-tracking memory reconsolidation is reduced by both adrenergic and NMDA receptor antagonism

This study shows that both propranolol and MK-801 disrupt appetitive goal-tracking memory reconsolidation in rats, with propranolol's effects being consistent across sexes and reminder types.

Ventral Hippocampus and NAc Core, but not Shell activity is required for well-learned instrumental memory destabilization

The paper investigates the role of ventral hippocampus and nucleus accumbens core and shell in destabilizing well-learned instrumental memory in rats, finding only the core is involved.

Memory destabilization during reconsolidation - A consequence of homeostatic plasticity?

This paper uses computational models to show that homeostatic plasticity can destabilize memories during reconsolidation, linking it to synaptic downscaling and behavioral effects of protein synthesis inhibition.

Post-reactivation mifepristone impairs generalisation of strongly-conditioned contextual fear memories

The paper tests if mifepristone disrupts strong contextual fear memories in rats, finding it reduces freezing to novel contexts but not the original context.

Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus

This study investigates how memory reconsolidation of sign-tracking behavior to an audiovisual compound stimulus can be modulated by MK-801 treatment, showing context-dependent effects based on re-exposure parameters.

Dopaminergic signalling is necessary, but not sufficient for cued fear memory destabilisation

The paper shows that nefiracetam and mifepristone together destabilize fear memory, but nefiracetam alone via D1 receptors is insufficient, and mifepristone may reduce fear expression independently of reactivation.

Different temporal windows for contextual fear memory destabilisation in the amygdala and hippocampus

This study investigates the temporal windows for CB1 receptor-mediated memory destabilisation during reconsolidation in the amygdala and hippocampus using pharmacological interventions in rats.

Reconsolidation-disruption diminishes spontaneous and stress-induced cocaine seeking

This study shows that disrupting reconsolidation of cocaine-seeking memories reduces spontaneous and stress-induced relapse in rats.