Author

Samuel McFadden

SIU MedicineORCID 0000-0002-2289-5066Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

Erin R. HascupiD· 4 shared Kathleen Quinn· 4 shared Mackenzie R. PeckiD· 4 shared Andrzej BartkeiD· 3 shared Kevin N. HascupiD· 3 shared Yimin FangiD· 3 shared Caleigh A. FindleyiD· 2 shared Jenelle E. Chapman· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersNeuroscience

Erin R. HascupORCID

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4 papers

Recent·Most cited

Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APPNL-F Mice

Samuel McFadden, Yimin Fang, Kathleen Quinn, Mackenzie R. Peck, Jenelle E. Chapman, Tiarra Hill, Andrzej Bartke, Erin R. Hascup, Kevin N. Hascup

This study shows that removing visceral adipose tissue in male APPNL-F mice improves metabolism and cognition, while females show different metabolic responses and no cognitive benefit.

Frontiers in Endocrinology · Mar 2, 2026Peer-reviewedNeuroscience

Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice

Samuel McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz, Caleigh A. Findley, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R. Hascup

This study shows that thermotherapy improves metabolism and cognition in male APP/PS1 mice but worsens spatial memory in female APP/PS1 mice.

Aging · Nov 29, 2024Peer-reviewedNeuroscience

Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice

Caleigh A. Findley, Samuel McFadden, Tiarra Hill, Mackenzie R. Peck, Kathleen Quinn, Kevin N. Hascup, Erin R. Hascup

This study examines glutamatergic neurotransmission and cognitive impairment in APPNL-F/NL-F mice, finding sex-dependent changes in glutamate release and cognitive deficits.

Journal of Alzheimer s Disease · Nov 1, 2024Peer-reviewedNeuroscience

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APPNL-F/NL-F Mice.

Yimin Fang, Mackenzie R. Peck, Kathleen Quinn, Jenelle E. Chapman, David Medina, Samuel McFadden, Andrzej Bartke, Erin R. Hascup, Kevin N. Hascup

This study shows that senolytic treatment improves cognition, metabolism, and adiposity in female APPNL-F/NL-F mice but not males.

GeroScience · Aug 9, 2024Peer-reviewedNeuroscience