Plasmin-mediated cleavage of GPIbα contributes to breakdown of platelet-von Willebrand factor complexes
Rowan Frunt, Elfie I Moesker, Kazuya Sakai, Masanori Matsumoto, Albert Huisman, Claudia Tersteeg, Hinde El Otmani
This study shows plasmin cleaves GPIbα, disrupting platelet-VWF complexes, but not VWF itself, and suggests GPIb shedding may be plasmin-mediated in TTP.
bioRxiv · Mar 25, 2026 · PreprintBiochemistry